The TRND program supports pre-clinical development of therapeutic candidates intended to treat rare or neglected disorders, with the goal of enabling an Investigational New Drug (IND) application. Learn more.
Submit a Pre-Clinical Collaboration Proposal
NCATS is accepting proposals on a rolling basis to collaborate with BrIDGs and TRND program scientists.
Work with Us
The TRND program is designed to encourage and speed the development of new treatments for diseases with high unmet medical needs. Find project details, scientific capabilities, information for applicants and more.
Therapeutics for Rare and Neglected Diseases (TRND)
TRND supports pre-clinical development from lead optimization through IND application.
TRND offers world-class in-house experts and connections to external resources.
Work with TRND
Partner with TRND to create and implement a therapeutic project plan for in-kind resources.
Why TRND Matters
There are more than 6,500 identified rare and neglected diseases, yet only about 250 treatments are available for these conditions. One reason is that limited numbers of patients can make gathering information and designing drug studies difficult. As a result, scientists often know little about the symptoms and biology of these conditions. Another obstacle is that some private companies may find it difficult to justify the cost of developing drugs for such small rare disease markets. Even in the case of infectious diseases — such as malaria — that inflict health burdens on large numbers of people in the developing world, the private sector often neglects therapeutic development because of insufficient economic incentives. Learn more about TRND.