Pre-Clinical Research Tools and Resources
NIH has developed several tools and resources to help scientists conduct pre-clinical research. Some of these resources and software tools are listed below.
Small Molecules, Compounds and Probes
PubChem is a freely accessible database of small organic molecules and their activities against biological assays.
NCATS Pharmaceutical Collection is a publicly available, Web-based application that provides complete information on active pharmaceutical ingredients, including small molecule drugs that have been approved by regulatory agencies from the United States, Canada, Europe and Japan, as well as all compounds that have been registered for human clinical trials.
Probes developed by NIH Chemical Genomics Center (NCGC) scientists, in collaboration with hundreds of extramural scientists, are freely accessible to the scientific community.
Assay Guidance Manual contains detailed information on developing appropriate assays for high-throughput screening projects.
NIH Chemical Genomics Center CurveFit serves as a public, stand-alone, open-source version of the Center’s own curve-fitting software. This application automatically fits and classifies thousands of dose-response curves.