2012 Tissue Chip Awards
On July 24, 2012, NIH issued 17 awards for research projects designed to create 3-D chips with living cells and tissues that accurately model the structure and function of human organs, such as the lung, liver and heart. In September of 2012, NIH issued two more awards, funded by other NIH Institutes and Centers. Twelve of these awards supported studies to develop 3-D cellular microsystems that represent a number of human organ systems. These bio-engineered devices aimed to be functionally relevant and reflect the complexity of the tissue of origin, including genomic diversity, disease complexity and pharmacological response. Seven awards explored the potential of stem and progenitor cells to differentiate into multiple cell types that represent the cellular architecture within organ systems. These could act as a source of cells to populate tissue chips.
In addition to organ systems, some of the awarded researchers developed tissue microsystems that target specific health conditions, such as cardiovascular disease, cancer, degenerative arthritis and gastrointestinal disease.
Tissue Chip News
NIH’s Tissue Chip program focuses on critical challenges in the drug discovery pipeline. Read the thematic issue of Experimental Biology and Medicine published on Sept. 1, 2014, that highlights these innovative projects.