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New Therapeutic Uses Funding Information

medical team sitting around table

NIH launched the New Therapeutic Uses collaborative program in May 2012. By pairing researchers with a selection of pharmaceutical industry agents, this innovative program aims to test ideas for new therapeutic uses, ultimately identifying promising new treatments for patients.

In June 2013 as part of a pilot initiative, NIH awarded $12.7 million to fund two-year and three-year cooperative agreements for nine projects in areas that include alcoholism, a type of progressive lung disease and tobacco cessation. If specific milestones are met, funded researchers will conduct pre-clinical validation, clinical feasibility studies or proof-of-concept clinical trials to test whether selected compounds are effective against a previously unexplored disease target.

In May 2014, NCATS issued four funding opportunities and provided information about partially developed therapeutic candidates (“agents”). For the first time in the program, the participating pharmaceutical companies have made available agents that are suitable for exploring pediatric indications.

Funding Announcements

Current Opportunities

In May 2014, NCATS issued the following four funding announcements:

  • PAR-14-213: Pre-application for the NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (X02)
  • PAR-14-212: Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3)
  • PAR-14-211: Limited Competition for NIH-Industry Program: Discovering New Therapeutic Uses for Existing Molecules (UH3)
  • PAR-14-210: Limited Competition for NIH-Industry Program: Discovering Pediatric New Therapeutic Uses for Existing Molecules (UH2/UH3)

Expired Announcements

These now-expired funding announcements include details on the application process, eligibility and associated timelines for the pilot program:

NOT-TR-14-001: Notice to Solicit Compounds for Inclusion in the NIH-Industry New Therapeutic Uses Program

NOT-TR-12-010: Technical Assistance Webinar for the NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules Limited Competition RFA-TR-12-004 (UH2/UH3) and RFA-TR-12-005 (UH3)

NOT-TR-12-008: Clarification for the NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules

PAR-12-203: A Pre-application for the NIH-Industry Pilot Program:  Discovering New Therapeutic Uses for Existing Molecules (X02)

RFA-TR-12-004: Limited Competition for NIH-Industry Pilot Program:  Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3)

RFA-TR-12-005: Limited Competition for NIH-Industry Pilot Program:  Discovering New Therapeutic Uses for Existing Molecules (UH3)

Related Links

Contact

Christine Colvis, 301-451-3903


New Funding Opportunities

NCATS announced new funding opportunities for its New Therapeutic Uses program. Apply now.


Technical Assistance Webinar

NCATS held a technical assistance webinar for applicants to the New Therapeutic Uses program on Thursday, May 29, 2014. Download the slides.


Frequently Asked Questions