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NCATS Chemical Genomics Center

The NCATS Chemical Genomics Center (NCGC) was created in 2004 as a Comprehensive Screening Center in the Molecular Libraries Probe Production Centers Network, part of the NIH Molecular Libraries Common Fund Program. The goals of NCGC in the NCATS Division of Pre-Clinical Innovation are to translate the discoveries of the Human Genome Project into biological and disease insights and ultimately new therapeutics for human disease through small molecule assay development, high-throughput screening, cheminformatics and chemistry.

NCGC programs include Assay Development and High-Throughput Screening, Chemistry Technology, RNAi and Toxicology in the 21st Century (Tox21).

In addition, NCGC is one of 12 centers that make up the National Cancer Institute’s Chemical Biology Consortium. These centers use the consortium’s high-throughput screening, informatics and chemistry resources to work on select cancer biology projects and move them through the therapeutics development pipeline, eventually into the clinic.

Through such programs, NCGC produces a variety of pre-clinical research tools, from informatics and software tools to an assay guidance manual and more than 200 molecular probes.

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NCGC staff: 301-217-5733

NCATS at Work

Researchers studying the biology of diseases often use scientific tools called biological probes. NCATS Chemical Genomics Center scientists exploring an enzyme family called lipoxygenases discovered three probes with the potential to treat diabetes, stroke and thrombosis.