Assay Development and High-Throughput Screening
The goal of the NCGC Assay Biology Teams in the NCATS Division of Pre-Clinical Innovation is to optimize biochemical, cellular and model organism-based assays requested or submitted by the biomedical research community for high-throughput small molecule screening. The results of these screens (probes) can be used to further interrogate protein and cell functions and biological processes relevant to physiology and disease. In addition, these probes can be further optimized to become potential lead candidates in the drug development pipeline.
NCATS at Work
With support from the Michael J. Fox Foundation for Parkinson's Research, experts from NCATS and the National Institute of Neurological Disorders and Stroke are leading a project using NCATS' chemical screening resources to advance development of potential therapeutics for a broad range of diseases.