Skip Over Navigation Links


TRND Projects

NCATS selects TRND projects based on their potential to move forward into human trials and transform patient care for rare and neglected diseases. Each project has the potential for success and ability to teach important lessons about rare and neglected disease drug development. Click on the links below to view active and completed TRND projects. Read the TRND fact sheet.

Active Projects

Completed Projects


Image of the cerebellum of the brain affected by Niemann-Pick type C1 at the near-end stage of the disease (Eunice Kennedy Shriver National Institute of Child Health and Human Development Photo)

On Jan. 7, 2015, NIH announced that NCATS and other NIH researchers are collaborating with Vtesse, Inc., to develop treatments for Niemann-Pick disease type C and other rare lysosomal storage disorders. Read the NIH news release.

New TRND Projects

Mosquito on finger

On Oct. 15, 2014, NCATS announced three new pre-clinical drug development projects aimed at finding treatments for malaria, Lassa fever, and two rare blood disorders: beta-thalassemia and sickle cell disease. Read the announcement.