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Profiling of the Tox21 10K Compound Library for Agonists and Antagonists of the Estrogen Receptor Alpha Signaling Pathway

The U.S. Tox21 program has screened a library of approximately 10,000 (10K) environmental chemicals and drugs in three independent runs for estrogen receptor alpha (ERα) agonist and antagonist activity using two types of ER reporter gene cell lines in a quantitative high-throughput screening (qHTS) format. The results demonstrate the feasibility of qHTS to identify environmental chemicals with the potential to interact with the ERα signaling pathway and the two different assay formats improve the confidence in correctly identifying these chemicals.

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