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Featured Scientific Publication

Design and validation of the EGFP-KRASG12V reporter cell line

A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein

Ras is a small GTPase that lies at the heart of numerous cellular signaling pathways governing growth, survival, and motility. Growth factor receptors activate Ras through Ras guanine nucleotide exchange factors (RasGEFs) that stimulate GTP loading on Ras.

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