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Case Western Reserve University Clinical and Translational Science Collaborative

Case Western faculty

Case Western Reserve University faculty and students have the opportunity to work collaboratively with partners in the CTSC, including the Cleveland Clinic, MetroHealth Medical Center and University Hospitals. (Case Western Reserve University Photo)

Cleveland, Ohio

Principal Investigator
Pamela B. Davis, M.D., Ph.D., Case Western Reserve University


The Clinical and Translational Science Collaborative, based at Case Western Reserve University, includes three hospital affiliates of the School of Medicine, the Cleveland Clinic, University Hospitals and MetroHealth Medical Center. Together, these hospitals cover 90 percent of the medical care delivered in the seven-county area surrounding Cleveland, Ohio, offering a wealth of clinical research opportunities. In addition, excellent programs based in the Frances Payne Bolton School of Nursing and the School of Dental Medicine, as well as those in the School of Medicine and its hospital affiliates reach into the community at many sites, some of which have become study sites in the CTSC. Together with the strong biomedical cores, the reach of these programs affords great opportunity for collaborative clinical research.



The Ohio State University Center for Clinical and Translational Science

Caroline Whitacre, Ph.D.

Caroline Whitacre, Ph.D., one of the world's most acknowledged authorities on autoimmune disease, is among hundreds of scientists at The Ohio State University Medical Center who translate innovative research findings into personalized patient care. (The Ohio State University Medical Center Photo)

Columbus, Ohio

Principal Investigator
Rebecca D. Jackson, M.D., The Ohio State University


The Ohio State University's Center for Clinical and Translational Science (OSU CCTS) brings together research teams and fosters innovation to translate science more quickly into patient care. In partnership with the Nationwide Children’s Hospital, the Center aims to:

  • Draw on the University’s diverse strengths to create an academic home for innovative, team-oriented clinical and translational science.
  • Nurture the career development of highly trained investigators, with an emphasis on innovation and science across disciplines.
  • Build an administrative infrastructure to conduct high-quality clinical and translational science applicable and relevant to communities.
  • Develop a portfolio of outstanding shared resources in support of transformative clinical and translational research.

The Center will continue to blend the traditional biomedical research process — basic scientific discovery, translated to the bedside, then disseminated into the community — with a public health approach (i.e., surveillance to prevention to response). Using this hybrid model, the Center will stimulate basic discovery and clinical research analysis, ultimately creating a robust translational science infrastructure. CCTS will conduct focused initiatives to develop new teams within an innovation ecosystem. Investigators will develop core competencies in research methodology; interpretation of results; implementation of findings; design thinking; and discipline-specific bench, clinical and community laboratory procedures. Investigators also will cultivate team leadership and business skills. The Center will build a clinical and translational science infrastructure to provide a range of scientific resources needed to conduct all forms of translational research.

University of Cincinnati Center for Clinical and Translational Science and Training

Frank McCormack, M.D.

Frank McCormack, M.D., director of University of Cincinnati's (UC) pulmonary division, is an expert on the rare lung disorder lymphangioleiomyomatosis (LAM). Collaborative research at UC and Cincinnati Children's Hospital Medical Center already has led to major discoveries about the progression and treatment of LAM. (University of Cincinnati Photo/Dan Davenport)

Cincinnati, Ohio

Principal Investigators
James E. Heubi, M.D., University of Cincinnati
Joel Tsevat, M.D., University of Cincinnati


The Center for Clinical and Translational Science and Training (CCTST) is transforming the research environment among the University of Cincinnati and its affiliated partners in the community and industry. The CCTST will coordinate and plan the overall direction of the university's research infrastructure and training opportunities; serve investigators' needs from project concept to completion; optimize skills and foster career development of both new and experienced investigators; and ensure that community input informs research processes, and that the university's discoveries are translated to the community.

Through Research Central, researchers will have easy access to centralized study design, biostatistical, bioinformatics, regulatory and community engagement support. The new Pilot & Collaborative Studies core will expand the pilot funding program at Cincinnati Children's Hospital Medical Center to the entire university. Greatly expanded educational offerings, including a new Certificate in Clinical and Translational Research, will be developed, building on the success of the Dean's Scholars in Clinical Research, as well as a master's degree in Clinical and Translational Research program.

Through the community engagement program, CCTST will further bidirectional research linkages with the local community, breaking down bureaucratic barriers by creating Institutional Review Boards that can coordinate community-based research. Expanding services, such as nursing/coordinator support and sample processing provided by the existing General Clinical Research Center and the Cincinnati Department of Veterans Affairs Medical Center, will promote patient-oriented research for populations in the community.

New translational technologies, including proteomics, drug discovery, imaging, nanomedicine, gene transfer and stem cell biology, and translational and molecular disease modeling, will be made more accessible to researchers.

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