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North Carolina

Duke Translational Medicine Institute

Nirmala Ramanujam, Ph.D.

Nirmala Ramanujam, Ph.D., professor of biomedical engineering at Duke University, is working to develop tools that use photonics to improve the effectiveness and efficiency of breast cancer therapy. (Duke University Photo/Butch Usery)

Durham, North Carolina

Principal Investigators

L. Ebony Boulware, M.D., Duke University
Jennifer S. Li, M.D., Duke University
James O. McNamara, M.D., Duke University


To speed the translation of scientific discoveries into improved patient outcomes, academic health and science systems must invest, transform and innovate to bring out their unique strengths. The Duke Translational Medicine Institute (DTMI) creates a research environment that stimulates bench-to-bedside translation by linking discovery science to a creative engine that speeds development of new technologies. DTMI also integrates clinical trials, registries and electronic health records in a learning health system where research and practice come together. Research priorities are driven by scientific merit and societal need, and resources are applicable across a full range of diseases and specialties. DTMI uses an updated institutional framework for research oversight and quality and continually evaluates academic productivity, efficiency and cost. To achieve these goals, the Institute:

  • Creates an integrated home for clinical and translational research by providing infrastructure and resources to serve investigators and trainees across the research spectrum.
  • Offers resources based on researchers’ common needs for education, biostatistics, biobanking, regulatory expertise, ethics, pilot funding and recruitment assistance.
  • Tailors offerings to specialized needs across research communities, such as early translation, proof of concept, and site- and population-based research, which require multisite trials, health services, implementation science and community-engaged research.

To integrate these resources, DTMI has built a new online portal for all trainees and investigators, MyResearchHome@Duke, and its counterpart, MyResearchTeam@Duke. These tools provide a single point of entry for all clinical and translational research at Duke, regardless of department or school.

North Carolina Translational and Clinical Sciences Institute

Researcher working in the lab

To speed the cycle of bringing discoveries from the research bench to the patient’s bedside, NC TraCS offers services and facilities that help researchers move their projects forward. (University of North Carolina at Chapel Hill Photo)

Chapel Hill, North Carolina

Principal Investigator
Marschall S. Runge, M.D., Ph.D., University of North Carolina at Chapel Hill


The North Carolina Translational and Clinical Sciences (NC TraCS) Institute combines the research strengths, resources and opportunities of the University of North Carolina at Chapel Hill, its new partner RTI International, and planning partner North Carolina Agricultural and Technical State University to accelerate clinical and translational research from health science discovery to dissemination to patients and communities. NC TraCS seeks to overcome barriers to translation by improving efficiency, training the research workforce and sharing successful, validated research methods. NC TraCS aims to:

  • Expand to support the full spectrum of clinical and translational research.
  • Focus on three strategic initiatives: next-generation technologies to transform clinical research and practice, new models and resources to accelerate drug development, and comparative-effectiveness research to provide definitive evidence of the benefits and harms of tests and treatments.
  • Train, support and motivate the next generation of clinical and translational researchers.

The unique research and training resources at NC TraCS will support the full range of clinical and translational research, from basic science to clinical application to policy change, to benefit patients across the state and nationally through the CTSA Consortium.

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