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Mayo Clinic Center for Clinical and Translational Science

Rochester, Minnesota

Principal Investigator
Sundeep Khosla, M.D., Mayo Clinic


The goal of the Mayo Clinic CTSA application is to present Mayo's vision for the integration and expansion of its innovative clinical and translational research activities, so that a highly functional academic home for clinical and translational research is developed at the Mayo Clinic. The Center for Clinical and Translational Science is founded on the Mayo Clinic's long-standing excellence in and commitment to clinical and translational research, which includes the support of key infrastructure and a commitment to career development. To achieve this goal, Mayo will take a comprehensive approach to the key elements of the CTSA Request for Applications and focus on enhancing: 1) clinical research core resources that provide innovative tools to investigators; 2) career development and education programs that prepare the next generation of investigators; 3) compliance and regulatory affairs support that ensures patient safety and privacy, and customer service-oriented approaches to support investigative teams; 4) community affairs support to enhance participation, diversity and community support for clinical and translational research; 5) collaboration with industry and clinical practices to translate research discoveries into routine clinical practice; and 6) continued and expanded institutional support that includes an academic home for clinical and translational research. the Mayo Clinic also proposes a consolidated governance plan that incorporates strong data-driven evaluation of each Center for Clinical and Translational Science element and the program as a whole. In principle, the CTSA program is consistent with the historical, conceptual and philosophical underpinnings of the Mayo Clinic, and this application clearly articulates how the overarching and transformative goals of the CTSA program can be met at Mayo. To summarize, the Mayo Clinic Center for Clinical and Translational Science will bring together all the resources of the five schools within the Mayo Clinic College of Medicine, and more than 100 years of scientific and medical research expertise, to discover innovative new methods that will speed the translation of research results into therapies, tools and patient care practices that impact all members of the local and national communities. This vision is entirely consistent with the stated mission of the Mayo Clinic to provide the best care to every patient, every day, through integrated clinical practice, education and research.

University of Minnesota Clinical and Translational Science Institute

Aaron Friedman, M.D. and Bruce Blazar, M.D.

Aaron Friedman, M.D. (left), vice president for health sciences and dean of the University of Minnesota Medical School, discusses a new method to replicate regulatory T cells for bone marrow transplant patients with Bruce Blazar, M.D., who leads the CTSI. Blazer is Regent's Professor of Pediatrics and a pioneer in the discovery and use of T cells to boost success for transplant patients.

Minneapolis, Minnesota

Principal Investigator
Bruce R. Blazar, M.D., University of Minnesota Twin Cities


The University of Minnesota (UMN) Clinical and Translational Science Institute (CTSI) creates an academic home to promote clinical and translational research. CTSI is developing an ongoing alignment with major statewide healthcare organizations and insurers, electronic networks, special and rural community populations, the state department of health, and the Mayo Clinic. As a result, CTSI is in a position to have a strong impact on workforce training, health care outcomes and policy in Minnesota.

CTSI aims to improve health and well-being by accelerating discoveries into practice, from the scientist's laboratory to the patient's bedside. UMN provides a full spectrum of research expertise and technologies to foster this acceleration.

The CTSI goals are to: 1) create an academic home and an adaptive, sustainable infrastructure to support clinical translational science research at UMN; 2) foster meaningful relationships and transparent interactions between UMN and our communities to improve health statewide; and 3) train and reward interdisciplinary clinical translational science teams at UMN and in our communities.

Increasingly integrated functions in university cores will support clinical translational science research trainees and junior faculty with learner-tailored curricula. Others will accelerate bench-to-bedside translation and commercial applications. The university's Biomedical Health Informatics initiative will provide networked clinical data and biospecimen resources while training future informatics scholars.

The CTSI vision is for an environment that transforms relationships in the health care community, forging a true partnership to facilitate discovery, translation and knowledge dissemination that identify and address changing community needs to have an ongoing positive impact on people's health.

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