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Northwestern University Clinical and Translational Sciences Institute

Dr. Stephan Schuele

Stephan Schuele, M.D. (right), leads the Northwestern University Comprehensive Epilepsy Center based at Northwestern Memorial Hospital. The Center's team of neurologists, neurosurgeons, radiologists, neuropsychologists, electrophysiologists and nuclear medicine specialists apply the latest advances in molecular biology, imaging and pharmacology to diagnose and treat epilepsy.

Evanston and Chicago, Illinois

Principal Investigator
Donald M. Lloyd-Jones, M.D., Sc.M., Northwestern University


The Northwestern University Clinical and Translational Sciences Institute (NUCATS) is dedicated to facilitating, supporting and promoting research that results in better medical treatments and improved health care. NUCATS is the physical home and central hub for translational research across the Northwestern University enterprise. The institute is composed of five centers, and participation spans several geographic locations, including the involvement of all four NU-affiliated hospitals and six NU schools located on two campuses: the Feinberg School of Medicine, the Kellogg School of Management, the McCormick School of Engineering and Applied Science, the School of Communication, the School of Education and Social Policy, and the Weinberg College of Arts and Sciences. Basic scientists, medical practitioners, community-based medical practitioners and community-based organizations are working together with leaders in the fields of communications, education, business and public health to eliminate barriers to innovation.

University of Chicago Institute for Translational Medicine

Chicago, Illinois

Principal Investigator
Julian Solway, M.D., University of Chicago


The ultimate goals of the University of Chicago (UC) CTSA program are: 1) to train scientists and health care providers at the university, partner institutions and community to determine the molecular underpinnings of disease and disease predisposition in any individual patient; 2) to develop, test, implement and make readily available to community residents personalized therapies directed toward those individual underpinnings; and 3) to do this in a way that is rigorous, valid, efficient, ethical and respectful of our community's needs and values. In a robust alliance with the Argonne national Laboratory, the Illinois Institute of Technology and two large health care organizations, the UC CTSA will undertake three bold new steps that will transform clinical and translational research: 1) creation of an Institute for Translational Medicine, a new university-wide structure to collect, integrate and disseminate the intellectual, organizational and resource infrastructure needed to promote and support multidisciplinary translational research collaborations; 2) synergistic research interaction with a new Urban Health Initiative which, through partnership with community stakeholders, aims to improve community health care access and quality, to build health literacy and trust throughout the community, to enhance a translational research program informed by and responsive to the needs of the community, and so to reduce health disparities; and 3) establishment of a new academic Committee on Clinical and Translational Science and of multiple novel training programs to encourage and develop careers in clinical and translational research, intended for high school students through university faculty and across the entire translational research spectrum. CTSA investigators will employ a systems medicine approach to leverage their particular expertise in social science, genetic medicine and integrative therapeutics.

University of Illinois at Chicago Center for Clinical and Translational Science

John Hetling

John Hetling, Ph.D., associate professor in bioengineering, is working on a CCTS-funded study to produce the first human data from the multi-electrode electro-retinogram, which maps retinal (eye) health. (Roberta Dupuis-Devlin Photo)

Chicago, Illinois

Principal Investigators

Larry Tobacman, M.D., University of Illinois at Chicago
Dimitri Azar, M.D., University of Illinois at Chicago
Robin J. Mermelstein, Ph.D., University of Illinois at Chicago


The University of Illinois at Chicago (UIC) Center for Clinical and Translational Science (CCTS) will fundamentally alter clinical and translational investigation at UIC and our partnering institutions. Harnessing our diverse backgrounds, interests and expertise, CCTS will catalyze collaborative thinking and innovation. The center will organize, finance and house the infrastructure, expertise and resources for clinical and translational investigators within a single academic home, crossing administrative boundaries to harness and enhance existing UIC resources.

CCTS' goals: 1) Create and develop an academic home for clinical translational research at UIC that will provide a flexible, adaptable infrastructure to stimulate collaborative thinking, generative discourse and collective action, facilitating clinical and translational investigation. This will include establishing a robust pilot grant program, a Clinical and Translational Science Academy, a Web-based and geographic single point-of-access for investigators, and a matchmaking service to identify novel collaborations. 2) Establish the research service infrastructure (six cores) to provide research support services. 3) Provide multifaceted educational experiences for pre- and postdoctoral trainees, junior faculty and established faculty who want to extend their thinking beyond current disciplinary boundaries.

The administrative reorganization represented by CCTS will lead to rationalization and integration of significant and mature UIC resources for clinical translational research. CCTS will add to these resources to produce not only something different, but something better for clinical translational researchers and trainees at UIC and at partner institutions.

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