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District of Columbia

Clinical and Translational Science Institute at Children's National

Lisa Guay-Woodford, M.D., with patient Michael Lewis

Lisa Guay-Woodford, M.D., principal investigator at CTSI-CN, talks with patient Michael Lewis during his visit to the Clinical Research Center. Lewis has mucopolysaccharidosis IVA (Morquio A syndrome). (Stephen Bobb Photo/Paula Darte)

Washington, District of Columbia

Principal Investigator
Lisa M. Guay-Woodford, M.D., Children's National Medical Center


The Clinical and Translational Science Institute at Children's National (CTSI-CN) offers a unique set of resources in translating discovery to improved health. CTSI-CN provides highly integrated, cost-effective, investigator-focused resources designed to overcome research barriers, promote collaborative research and provide research training in the area of children's health. With an emphasis on health disparities and childhood antecedents to adult diseases, this center will build upon its pediatric research strengths in areas such as rare diseases, asthma and neurodevelopmental disabilities to collaborate with a national network of 1,200 community health centers.

The specific objectives of CTSI-CN are to: 1) provide state-of-the-art, flexible resources required by clinical and translational researchers, 2) promote multidisciplinary clinical and translational research (CTR), 3) strengthen CTR education and training for diverse trainees at all stages of career development, 4) promote demographic diversity and address health disparities, 5) incorporate effective and sustained collaboration with community partners, 6) ensure research efficiency, and 7) establish bidirectional collaborations with the CTSA network. CTSI-CN lends its unique perspective on pediatric health issues and urban health disparities to the already distinguished members of the CTSA network.

Some key features of CTSI-CN are to expand CTR education and training, making it available from high school through mid-career, encourage community-based research at diverse locations, and overcome gaps in innovative research methodologies to support research.

Georgetown-Howard Universities Center for Clinical and Translational Science

Thomas Mellman (left) and Joseph Verbalis (right)

Thomas Mellman, M.D. (left), of Howard University and Joseph Verbalis, M.D., of Georgetown University share leadership of GHUCCTS. (Georgetown University Photo)

Washington, District of Columbia

Principal Investigators
Joseph G. Verbalis, M.D., Georgetown University
Thomas A. Mellman, M.D., Howard University


The Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) is a collaborative research center that includes two major universities and three affiliated hospital and research systems.

The specific aims of GHUCCTS are to accelerate improvements in human health by stimulating innovative, multidisciplinary and cross-institutional research among GHUCCTS investigators; to support the careers of clinical and translational investigators through a variety of educational programs paired with focused mentorship; and to enhance local and national clinical and translational research in underserved populations, including minorities, the elderly and those with disabilities.

To accomplish these aims, the GHUCCTS team integrates existing research and training programs with an innovative infrastructure to enhance practice-, laboratory- and community-based clinical and translational research. GHUCCTS includes a coordinated multi-institutional biomedical informatics infrastructure, an expanded clinical research operation with new community-based clinical research units, a new community engagement resource to support and enhance community-based research, and expanded resources in regulatory knowledge and ethics. GHUCCTS also supports collaborative research projects, using the supercomputing and translational tools of the Oak Ridge National Laboratory to explore and develop novel translational methodologies.

Resource integration across the GHUCCTS institutions is accompanied by a joint research education, training and career development program, including new master's degree and scholars' programs in clinical and translational science. GHUCCTS multidisciplinary and cross-institutional research enables the Washington, D.C., community to benefit from the generation and application of new discoveries in clinical and translational science.

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