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Ketamine Metabolite Fights Depression

NCATS scientists helped identify a chemical byproduct created as the body breaks down ketamine — a finding that has potential for treating depression.


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NCATS pre-clinical programs and resources focus on key obstacles and inefficiencies in the translational process, overcoming bottlenecks that slow the development of new treatments for patients.

Learn more about how to access NCATS programs and expertise.

Pre-Clinical Innovation

NCATS develops novel approaches to improve the process of joining basic science discoveries with initial testing of therapies in humans. 

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Improving the Drug Development Process

Creating and testing innovative methods to improve and accelerate the drug development process and find new treatments for patients faster.

Repurposing Drugs

Discovering new uses for approved drugs to provide the quickest possible transition from bench to bedside.

Testing & Predictive Models

Developing better model systems for drug and toxicity testing.

Core Technologies

Using state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities.