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Videos

Watch videos of NCATS leadership, researchers and grantees in action, including high-quality B-roll of the Center’s robotic screening platform.

Videos

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Acoustic chemical compound dispense

Runtime: 1:15      
Date: 2021      
Please contact NCATS to obtain the raw video footage files.      
Video courtesy of NIH's National Human Genome Research Institute.

Acoustic compound dispense and assay detection protocols running simultaneously

Multiple plates are acoustically dispensed with nanoliters of chemical compounds. Shows robotic arm 1 unloading assay and chemical compound source plates from incubator and storage hotel respectively, removing the metal lids and placing onto the acoustic dispenser. This also includes the robotic arm retrieving the plates once finished, replacing lid and loading back into storage locations. In the background arm 3 is also working to process plates for an assay detection protocol.

Runtime: 9:26      
Date: 2021      
Please contact NCATS to obtain the raw video footage files.

Acoustic dispense and plate unload/load

Nanoliters of a library of chemical compounds are dispensed using acoustic energy into a 1536-well assay plate. Once it finishes the dispense the lifter presents the plate and the robotic arm unloads the current plate, replaces the metal lid and returns it to the incubator. The next assay plate in the queue is loaded onto the acoustic dispenser after the lid is removed by the robotic arm.

Runtime: 2:11      
Date: 2021      
Please contact NCATS to obtain the raw video footage files.     

Assay detection protocol using arm 3 of Primary screening system

1536-well assay plates containing cells and chemical compounds are being loaded onto a solenoid valve low volume liquid dispenser, after the metal lid is removed, which is adding microliters of a detection reagent into every well. The lid is then put back on and the assay plate is loaded into a storage hotel for incubation. The final step in the protocol is removing the lid and loading the plate into the multimode reader to collect the resultant data.

Runtime: 4:06     
Date: 2021     
Please contact NCATS to obtain the raw video footage files.     

Automated tissue culture robot and Arm 1 of Primary screening system

In the background the automated tissue culture platform is running a process where you see the arm within going through specific steps. Simultaneously arm 1 of the Primary screening system is unloading the assay plate as well as the chemical compound acoustic source plate into their respective locations.

Runtime: 2:49      
Date: 2021      
Please contact NCATS to obtain the raw video footage files.     

Automated tissue culture robot

Reagents are being dispensed and emptied from a cell flask as part of an automated cell splitting process run on the system which also includes removing and replacing the flask cap as needed and perturbing to wash flask inner surface thoroughly.

Runtime: 2:39      
Date: 2021      
Please contact NCATS to obtain the raw video footage files.     

End of cell splitting protocol

Cells added into a new flask, returned to incubator and pipette disposed of by robotic arm.

Runtime: 1:13      
Date: 2021      
Please contact NCATS to obtain the raw video footage files.     

How NCATS Compound Management Speeds New Therapies

Kelli Wilson, Ph.D., director of Compound Management at NCATS, explains how the NCATS Compound Management group supports researchers via compound storage, registration, shipping and reformatting.

Runtime: 2:48      
Date: 2024 

A version of this video with audio description is available.

I Am Translational Science: Anne Pariser, M.D., NCATS

Anne R. Pariser, M.D., NCATS, ORDR, director of the NCATS Office of Rare Diseases Research, discusses how focusing on research barriers that are common to many rare diseases can help speed the development of treatments for multiple diseases. She discusses the NCATS-led Platform Vector Gene Therapy program (PaVe-GT), which aims to increase the efficiency of gene therapy trial startup by using a standardized process.

Posted March 3, 2021

Dr. Pariser retired from NCATS in February 2022.

A version of this video with audio description is available.

I Am Translational Science: Brittany M. Haynes, Ph.D., NCATS

As a cancer biology researcher, Brittany M. Haynes, Ph.D., learned firsthand the challenges that keep laboratory discoveries from becoming medical treatments. Now, as a scientific program specialist in the Education Branch at NCATS, Dr. Haynes helps young scientists acquire the translational science skills needed to pursue a broad range of scientific careers. She explains how the team sport of translational science shortens a treatment’s journey from benchtop to bedside.

Posted October 20, 2020

Dr. Haynes left NCATS in October 2022.

A version of this video with audio description is available.

I Am Translational Science: Carleen Klumpp-Thomas, M.S., NCATS

NCATS’ Carleen Klumpp-Thomas has always been fascinated by viruses. Now that interest is helping to drive her work collaborating with others at NIH on a study to determine the spread of COVID-19 in the United States, especially among people who might not have known they were infected.

Posted August 13, 2020

A version of this video with audio description is available.

I Am Translational Science: Chang Hee Kim, Ph.D., GoDiagnostics (GoDx)

Chang Hee Kim, CEO of GoDx, talks about what it’s like to conduct research during a pandemic and how a translational science approach is essential to fighting COVID-19. With funding from NCATS’ Small Business Innovation Research program, GoDx is adapting its technology platform into a quick, simple and inexpensive approach that could detect the novel coronavirus from nasopharyngeal or saliva samples in less than 30 minutes.

Posted July 29, 2020

A version of this video with audio description is available.

I Am Translational Science: Christopher Austin, M.D., Flagship Pioneering

Christopher P. Austin, M.D., CEO-Partner at Flagship Pioneering and former NCATS director, says that a revolution in basic research has increased our understanding of diseases but there has not been a commensurate increase in our ability to diagnose, treat and cure them. He explains how NCATS and translational science focus on developing solutions to problems along the path of turning scientific discoveries into treatments to benefit patients. Learn more about the impact and potential future of translational science in Dr. Austin’s article, “Opportunities and Challenges in Translational Science.”

Posted July 19, 2021

A version of this video with audio description is available.

I Am Translational Science: Hongfang Liu, Ph.D., Mayo Clinic

Hongfang Liu, Ph.D., program director for informatics at Mayo Clinic, is experienced in using clinical data for translational science research and improving health care delivery. Dr. Liu explains how collaborating with experts in other disciplines to build the National COVID Cohort Collaborative (N3C) Data Enclave will advance the science behind COVID-19 to deliver health care interventions and treatments.

Posted November 24, 2020

A version of this video with audio description is available.

I Am Translational Science: Kirill Gorshkov, Ph.D., NCATS

Kirill Gorshkov was part of the team at NCATS conducting research to respond to the COVID-19 pandemic. Dr. Gorshkov talks about his role on multiple projects and how earlier translational science efforts laid the groundwork for NCATS to quickly mobilize for COVID-19 research.

Posted August 6, 2020

A version of this video with audio description is available.”

I Am Translational Science: Lucie Low, Ph.D., NCATS

As the scientific program manager of the trans-NIH Tissue Chip for Drug Screening program, NCATS’ Lucie A. Low, Ph.D., works with diverse teams across the country to help develop and research tissue chips. She highlights the importance of seeking solutions through teamwork and collaboration in order to accelerate the translation of observations into interventions to improve health.

Posted February 8, 2021

Dr. Low left NCATS in June 2022.

A version of this video with audio description is available.

I Am Translational Science: Mustafa Sahin, M.D., Ph.D., Boston Children’s Hospital, Harvard Medical School

Mustafa Sahin, M.D., Ph.D., child neurologist at Boston Children’s Hospital and Harvard Medical School, shares how advances in translation have helped his team provide new treatments to young patients with rare neurodevelopmental disorders. Dr. Sahin, who is part of the NCATS-led Rare Diseases Clinical Research Network, discusses his hopes for better tools, such as biomarkers, to identify improvements in brain function and behavioral outcomes of patients.

Posted February 22, 2021

A version of this video with audio description is available.

I Am Translational Science: Sarah Dunsmore. Ph.D., NCATS

Sarah E. Dunsmore, Ph.D., highlights the importance of technology and NCATS’ ability to share data during the pandemic. In addition to her current role at NCATS, Dr. Dunsmore also serves as the project manager for ACTIV-6, which aims to provide evidence-based treatment options for the majority of adults with COVID-19 who have mild to moderate symptoms and are not sick enough to be hospitalized. She explains how the initiative is unique compared to the other ACTIV trials, which focus more on the severe effects of COVID-19.

Posted December 7, 2021

A version of this video with audio description is available.

Inside the NCATS Laboratories

Take a video tour of our labs and see firsthand how our researchers work to get more treatments to more patients more quickly.

Runtime: 7:12     
Date: August 2015

Meet a Fellow: Olive Jung

Olive Jung was a predoctoral fellow in DPI’s Early Translation Branch, with a focus on advancing the search for therapies targeting central nervous disorders. As an M.D./Ph.D. candidate, she worked at NCATS to develop 3-D models of the blood–brain barrier and the human lung to sharpen clinical predictability when promising drug compounds move from the laboratory into human trials. Intramural collaboration between NCATS and other NIH institutes and centers drew Olive to NCATS for her graduate research work. In this video, she explains how NCATS’ translational science training will help her bridge translational research and clinical practice later in her medical career. Learn more about the Graduate Partnerships Program.

Posted November 23, 2021

Meet a Fellow: Vukasin Jovanovic, Ph.D.

Vukasin Jovanovic, Ph.D., is a senior postdoctoral fellow in DPI’s Stem Cell Translation Laboratory, with a focus on developing human induced pluripotent stem cells (iPSC) for clinical applications. His NCATS research led to a new method that turns iPSCs faster and more efficiently into astrocytes faster and more efficiently. Astrocytes are a key brain cell type implicated in such diseases as autism, epilepsy and Alzheimer’s disease. In this video, Vukasin explains how NCATS’ translational science training, cutting-edge technology and team-based approach are advancing his career goals and accelerating his mission to find solutions for unmet medical needs. Learn more about postdoctoral training in NCATS research groups.

Posted November 23, 2021

NCATS Overview

Learn more about the mission and scientific focuses of the Center.

Runtime: 5:16      
Date: November 2013      
Right-click to download this video (MP4 - 304MB)

Primary screening system

Arms 1 and 3 on the Primary screening system are working simultaneously on parallel processes. Microtiter plates are loaded onto the necessary devices, an operation is performed per the associated protocol and they are returned to the original storage location.

Runtime: 1:36      
Date: 2021      
Please contact NCATS to obtain the raw video footage files.      

Rare Disease Patient Profiles: Jillian Clegg

Jillian Clegg has two sons with MED23 gene defect, a condition that causes intellectual disability and affects the neuromotor system.

Runtime: 3:31      
Date: February 2016      
Right-click to download this video (MP4 - 223MB)

Rare Disease Patient Profiles: Rachel Daniels

Rachel Daniels’ daughter Alani has congenital generalized lipodystrophy. Alani’s body is unable to store fat under her skin, and any fat she does take in can connect to organs such as the heart and liver, causing health complications.

Runtime: 3:29      
Date: February 2016      
Right-click to download this video (MP4 - 220MB)

Rare Disease Patient Profiles: Marcela Ferrada

Marcela Ferrada was diagnosed with an autoimmune disease called relapsing polychondritis, a rare degenerative disease characterized by recurrent inflammation of the cartilage in the body. Deterioration of the cartilage may affect any part of the body where cartilage is present. The ears, larynx and trachea may become “floppy,” and the bridge of the nose can collapse into a "saddlenose" shape. The aortic heart valve may also be affected.

Runtime: 2:35      
Date: February 2016      
Right-click to download this video (MP4 - 164MB)

Rare Disease Patient Profiles: Michael and Rachel Harris

Michael and Rachel Harris’s son has Vici syndrome, a multisystem congenital disorder characterized by agenesis (failure to develop) of the part of the brain called the corpus callosum. Symptoms can include cataracts, hypopigmentation of the eyes and hair, cardiomyopathy and combined immunodeficiency.

Runtime: 2:10      
Date: February 2016      
Right-click to download this video (MP4 - 137MB)

Rare Disease Patient Profiles: Jessica McQuillen

Jessica McQuillen has a condition called HHT that causes massive nosebleeds and can cause bleeding elsewhere in the body.

Runtime: 3:07      
Date: February 2016      
Right-click to download this video (MP4 - 198MB)

Rare Disease Patient Profiles: Joe Murray

Joe Murray’s daughter is affected by a connective tissue disorder called EB that causes the skin to be very fragile. The slightest friction can cause open blisters, wounds and chronic pain.

Runtime: 3:43      
Date: February 2016      
Right-click to download this video (MP4 - 236MB)

Rare Disease Patient Profiles: Megan O’Boyle

Megan O’Boyle’s daughter Shannon O’Boyle suffers from Phelan-McDermid syndrome, a rare condition that can cause autism, epilepsy and intellectual disabilities.

Runtime: 2:45      
Date: February 2016      
Right-click to download this video (MP4 - 174MB)

Rare Disease Patient Profiles: Jennifer Payne

Jennifer Payne discusses living with PKU, a liver enzyme deficiency caused by the inability to metabolize an essential amino acid called phenylalanine. Left untreated, PKU results in psychological disorders, neurological deterioration, mental illness and brain damage.

Runtime: 2:48      
Date: February 2016      
Right-click to download this video (MP4 - 177MB)

Rare Disease Patient Profiles: Stephanie Perron

Stephanie Perron’s son, Teddy, has been diagnosed with MELAS (mitochondrial disease complex 3 with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes) syndrome that affects many of the body’s systems, particularly the nervous system and muscles.

Runtime: 1:45      
Date: February 2016      
Right-click to download this video (MP4 - 110MB)      
Video courtesy of FasterCures.

Rare Disease Patient Profiles: Suzanne Ripley

Suzanne Ripley has two sons who suffer from an ultra-rare condition, glutathione synthetase disorder, which is a deficiency of the enzyme glutathione synthetase. The severe form of the disease can affect infants, causing progressive neurological symptoms, such as impairment in the acquisition of skills requiring the coordination of muscular and mental activities (psychomotor retardation), varying degrees of intellectual disability, seizures and diminished coordination of voluntary movements.

Runtime: 3:45      
Date: February 2016      
Right-click to download this video (MP4 - 239MB)

Tox21 Robot

B-roll of the high-speed robot screening system for the Toxicology in the 21st Century initiative.

Runtime: 9:20      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

NCATS Chemical Genomics Center (right-to-left pan)

Right-to-left pan of the front of the NCATS Early Translation Branch’s chemical genomics production line showing chemical prep area, incubator and library carousel of compounds.

Runtime: 0:20      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Three Tox21 robots (extreme wide shot)

A tilt-down wide shot showing three yellow robot arms moving plates in the testing production line.

Runtime: 0:31      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Front of production line (extreme wide angle)

A wide angle establishing a shot of the front of the production line.

Runtime: 0:13      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Robots two and three working (medium shot)

A medium shot of robots two and three moving plates along the production line.

Runtime: 0:18      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Two robots moving (medium shot)

Medium tilt-down shot of robots one and two moving plates along the production line.

Runtime: 0:26      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Multiple plates moving (wide shot)

Wide shot, from an angle, of two robots moving plates along the production line.

Runtime: 0:34      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Two robots exchanging plates (wide shot)

Wide shot, from the side, showing two robots moving plate across transfer platform.

Runtime: 0:19      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Transfer plate (extreme close-up)

Extreme close-up of a transfer plate.

Runtime: 0:14      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Tilt-down feeding the detector (close-up)

Close-up tilt-down shot of a robot arm placing a reaction plate on a detector that measures the reactions.

Runtime: 0:23      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Microfluidics pipetting machine (extreme close-up to wide shot)

Extreme close-up pulls back show a microfluid pipetting machine that puts chemicals in plates.

Runtime: 0:18      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Robot feeding stacking rack (wide shot with pan)

Wide shot of a robot arm moving a plate to a stacking rack.

Runtime: 0:09      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Control panel (wide shot)

Wide shot of the control panel for the production line with a robot arm moving in the background.

Runtime: 0:12      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Chemistry station (wide shot)

Wide shot of the chemistry station where chemicals are mixed and added to the pipeline with the robot moving in the background.

Runtime: 0:16      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Molecular libraries (wide shot)

Static wide shot showing the molecular libraries end of the production line with a library carousel rotating.

Runtime: 0:11      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Two robots feed microfluidics system (medium shot)

Medium shot of two robots moving plates across the transfer station in front of a fluid-handling system.

Runtime: 0:12      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Molecular library carousel (medium shot)

Medium shot of the molecular library carousel rotating to make volumes available to production line.

Runtime: 0:08      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Fluid handling (wide shot)

Wide shot of the fluid supply and handling end of the production line.

Runtime: 0:15      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Technician cleaning sensor (wide shot)

Medium, over-the-shoulder shot of a technician cleaning the sensor on a bench-top lab machine.

Runtime: 0:07      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Technician cleaning plates (wide shot)

Wide shot of a technician removing reaction plates from tray and cleaning them on a lab bench.

Runtime: 0:20      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Technician laying out plates (wide shot to medium shot)

Wide shot of a technician laying out plates on lab bench, with a zoom in to a medium shot as he cleans the plates.

Runtime: 0:33      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Technician cleaning many plates (extreme close-up)

Extreme close-up of a technician cleaning reaction plates on a lab bench.

Runtime: 0:10      
Date: 2010      
Video courtesy of NIH's National Human Genome Research Institute.

Last updated on March 11, 2024